2012 was the year in which Britain celebrated the 2012 Olympics, which were held in London, and the Queen's diamond jubilee. Additionally, 2012 was the 27th year of EastEnders.
- 1st - The death of Pat Evans
- 1st - The return of David Wicks
- 9th - Leslie "Les" Coker makes a short appearance
- 10th - Arrival of Ray Dixon
- 13th - Departure of David Wicks and shock return of Simon Wicks
- 17th - Arrival of Gethin Williams
- 26th - Arrival of Sasha Dixon
- 27th - Departure of Jane Beale and Gethin Williams
- 30th - Derek Branning threatens Tyler and Anthony Moon to give him £4,000
- 31st - Anthony Moon and Amira Masood start dating
- 2nd - Derek thinks that Anthony and Tyler grassed him up to the police, so he doubles the payment
- 6th - Roxy Mitchell and Jack Branning sleep together
- 7th - Kim Fox slaps Ray Dixon and Sinclair
- 1st - Mandy's mother, Lorraine, returns to the square.
- 1st - Michael announces that he is no longer helping Janine and her baby.
- 2nd - It is revealed that Yusuf left everything he owned to Zainab in his will.
- 2nd - Michael proposes to Janine, who accepts.
- 8th - Amira leaves Walford.
- 19th - Heather Trott is killed by Ben Mitchell
- 25th - Mandy leaves Walford.
- 13th - Sharon Mitchell returns to Walford.
- 24th - Ben Mitchell is finally sent to prison for the murder of Heather and is sentenced to three years and charged with manslaughter.
- 30th - Anthony Moon leaves Walford.
- 6th - Carly Wicks returns to Walford for a short guest stint.
- 7th - Carly leaves Walford the following day, taking Shirley Carter with her following the trauma she has suffered after Heather's death.
- 20th - Kat's mystery lover is revealed to be Derek Branning.
- Ian Beale
- Dot Branning
- Simon Wicks (Only 13 January 2012)
- Pat Evans (Until 1 January 2012)
- Ricky Butcher (Until 17 January 2012)
- Janine Butcher
- Phil Mitchell
- Mandy Salter
- Carol Jackson
- Bianca Butcher
- David Wicks (Until 13 January 2012)
- Lucy Beale
- Ben Mitchell
- Derek Branning
- Billy Mitchell
- Liam Butcher
- Kat Moon
- Mo Harris
- DCI Jill Marsden
- Patrick Trueman
- Alfie Moon
- Bobby Beale
- Jane Beale (Until 27 January 2012)
- Jean Slater
- Denise Fox
- Max Branning
- Tanya Branning
- Abi Branning
- Lauren Branning
- Shirley Carter
- Jay Mitchell
- Heather Trott (Until 19th March 2012)
- Zainab Khan
- Roxy Mitchell
- Tamwar Masood
- Masood Ahmed
- Jack Branning
- Oscar Branning
- Christian Clarke
- Whitney Dean
- Morgan Butcher
- Tiffany Butcher
- Amy Mitchell
- Syed Masood
- Amira Masood (Until 8th March 2012)
- George Trott
- Kim Fox
- Qadim Shah (Until 6 January 2012)
- Afia Masood
- Kamil Masood
- Michael Moon
- Tommy Moon
- Shenice Quinn
- Tyler Moon
- Norman Simmonds (Until 2 January 2012)
- Lola Pearce
- Anthony Moon
- Andrew Cotton
- Rose Cotton
- Leslie "Les" Coker (Until 9 January 2012)
- Ray Dixon
- Gethin Williams (Until 27 January 2012)
- Sasha Dixon